2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154359
    2’-O-Acetyl-3’,5’-bis-O-benzoyl-6-aza-xylo uridine
    2’-O-Acetyl-3’,5’-bis-O-benzoyl-6-aza-xylo uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Acetyl-3’,5’-bis-O-benzoyl-6-aza-xylo uridine
  • HY-W415119
    2',3'-Di-O-acetyl-D-uridine
    2',3'-Di-O-acetyl-D-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2',3'-Di-O-acetyl-D-uridine
  • HY-154684
    5-Benzylamino carbonyl-3’-O-acetyl-2’-O-methyl-5’-O-DMTr-uridine
    5-Benzylamino carbonyl-3’-O-acetyl-2’-O-methyl-5’-O-DMTr-uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Benzylamino carbonyl-3’-O-acetyl-2’-O-methyl-5’-O-DMTr-uridine
  • HY-180713
    2-Hydroxy-3-(4-hydroxyphenyl)propenoate
    2-Hydroxy-3-(4-hydroxyphenyl)propenoate (4-Hydroxy-enol-phenylpyruvate) is a nucleoside metabolite.
    2-Hydroxy-3-(4-hydroxyphenyl)propenoate
  • HY-154570
    3’-N-Acetyl-3’-amino-3’-deoxy-2’,5’-di-O-acetyluridine
    3’-N-Acetyl-3’-amino-3’-deoxy-2’,5’-di-O-acetyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-N-Acetyl-3’-amino-3’-deoxy-2’,5’-di-O-acetyluridine
  • HY-180565
    17-Hydroxylinolenic acid
    17-Hydroxylinolenic acid is a nucleoside metabolite.
    17-Hydroxylinolenic acid
  • HY-W743845
    19-Oxotestosterone
    19-Oxotestosterone is a nucleoside metabolite.
    19-Oxotestosterone
  • HY-152976
    N4-Benzoyl-7’-O-(4,4’-dimethoxytrityloxy)morpholinocytosine
    N4-Benzoyl-7’-O-(4,4’-dimethoxytrityl oxy)morpholinocytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    N4-Benzoyl-7’-O-(4,4’-dimethoxytrityloxy)morpholinocytosine
  • HY-154258
    Rev 2’-O-MOE-5MeU-5’-amidite
    Rev 2’-O-MOE-5MeU-5’-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Rev 2’-O-MOE-5MeU-5’-amidite
  • HY-154677
    2-Aminopurine-9-beta-D-(2’-deoxy)riboside
    2-Aminopurine-9-beta-D-(2’-deoxy)riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Aminopurine-9-beta-D-(2’-deoxy)riboside
  • HY-154072
    2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-trifluoromethyluridine
    2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-trifluoromethyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-trifluoromethyluridine
  • HY-154141
    3’-Beta-C-Ethynyl-5-fluorouridine
    3’-Beta-C-Ethynyl-5-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Beta-C-Ethynyl-5-fluorouridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    3’-Beta-C-Ethynyl-5-fluorouridine
  • HY-152652
    5’(R)-C-Methylguanosine
    5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    5’(R)-C-Methylguanosine
  • HY-111807
    Locked nucleic acid 1
    Locked nucleic acid 1 is a derivative of LNA-type nucleoside.
    Locked nucleic acid 1
  • HY-152776
    2-Amino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
    2-Amino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Amino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
  • HY-180693
    erythro-5-Phosphooxy-L-lysine
    erythro-5-Phosphooxy-L-lysine is a phospho amino acid.
    erythro-5-Phosphooxy-L-lysine
  • HY-152874
    5-N-(t-Butyloxycarbonylmethyl)-N-trifluoro acetyl-aminomethyl-2’-O-methyluridine
    5-N-(t-Butyloxycarbonylmethyl)-N-trifluoro acetyl-aminomethyl-2’-O-methyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-N-(t-Butyloxycarbonylmethyl)-N-trifluoro acetyl-aminomethyl-2’-O-methyluridine
  • HY-152371
    1,N6-Etheno-9-(β-D-xylofuranosyl)adenosine
    1,N6-Etheno-9-(β-D-xylofuranosyl)adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1,N6-Etheno-9-(β-D-xylofuranosyl)adenosine
  • HY-180741
    (2Z,4E)-5-Hydroxypenta-2,4-diene-1,2,5-tricarboxylic acid
    (2Z,4E)-5-Hydroxypenta-2,4-diene-1,2,5-tricarboxylic acid is a 5-hydroxypenta-2,4-diene-1,2,5-tricarboxylic acid.
    (2Z,4E)-5-Hydroxypenta-2,4-diene-1,2,5-tricarboxylic acid
  • HY-153236
    Py-MAA-Val-Cit-PAB-DX8951
    Py-MAA-Val-Cit-PAB-DX8951 is a purine toxin. Py-MAA-Val-Cit-PAB-DX8951 can be used as an intermediate in the synthesis of antibody-drug conjugates.
    Py-MAA-Val-Cit-PAB-DX8951